|
KMID : 1123920200340050229
|
|
Korean Journal of Oriental Physiology and Pathology
2020 Volume.34 No. 5 p.229 ~ p.237
|
|
|
Antioxidant and Hangover Cure Effects of Compound Prescription Containing Phyllanthus emblica and Azadirachta Indica Leaf Extract
|
|
Lee Su-Bin
Joo In-Hwan
Park Jong-Min
Han Su-Hyun
Wi Young-Joon
Kim Dong-Hee
|
|
|
Abstract
|
|
|
|
The purpose of this study was to investigate the antioxidant and hangover cure effects of compound prescription containing Phyllanthus emblica and Azadirachta Indica leaf extract (CP). In vitro experiments, HepG2 cells were induced oxidative stress by hydrogen peroxide (H2O2) and treated with CP at 50, 100, 200 ㎍/㎖ concentration. Antioxidant enzyme (superoxide dismutase (SOD), catalse (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) activity and glutathione (GSH) content were decreased by hydrogen peroxide-induced oxidative stress, but CP was increased that. In vivo experiments, experiment rats were orally administered alcohol 3 g/kg and, after 30 min administered CP 200 ㎎/㎏. After 1 and 3 h of alcohol administration, blood was collected from the tail vein, while after 5 h, blood was collected from the heart. CP modulates alcohol dehydrogenase (ADH) and acetaldehyde level, thereby decreased alcohol level in serum. Also, CP decreased the levels of aspartate aminotransferase (AST) and alkaline phosphatase (ALP). These results suggest that CP has antioxidant effects and alleviates alcohol hangover symptoms.
|
|
|
KEYWORD
|
|
|
Alcohol, Antioxidant, Azadirachta Indical, Pyllanthus emblicand, Hangover
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|